Endocrine Disorder Practice Test 2026 – Complete Exam Prep Guide

In Addison’s disease, loss of aldosterone causes the kidneys to waste sodium and water, leading to dehydration and volume depletion. To counter these losses, fluid intake is increased beyond normal maintenance. A practical target is about 3 liters (3000 mL) of fluids per day, often paired with adequate salt intake, to help prevent dehydration. Individual needs can vary with climate, activity, and hormone replacement therapy, but 3000 mL is a common recommendation for maintaining hydration in many adults with this condition. The smaller daily volumes listed are typically not sufficient to offset the fluid losses from mineralocorticoid deficiency.